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drug discovery in the ubiquitin field

Access to well defined ubiquitinated peptides and conjugates, which could so far not be routinely produced (bio)chemically, is of paramount importance for screening assays for the identification of new drugs, as well as for fundamental research and structural studies. Find out about how our reagents enables research in the three stages of early drug discovery. 

target

Identify and validate your target using UbiQ Probes.

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lead

Screen your compounds targeting DUBs and Ubl proteases using UbiQ Assay reagents.  

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lead on target

Our reagents enable you in lead on target validation and lead optimization.

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reagents

about our products

UbiQ develops and commercializes ubiquitinated peptides, ubiquitin-based reagents and high throughput assays, which enable and expedite drug discovery in the rapidly expanding ubiquitin field. UbiQ, founded in 2010, is a spin-out of the Netherlands Cancer Institute (NKI), Amsterdam. 

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custom made reagents

With our UbiQ technologies we are able to fully synthesize site-selective ubiquitinated peptides of native conformation, using automated solid phase peptide synthesis. This enables us to synthesize any custom made peptides.

news

  • UbiQ-news: Reagents for your SARS-CoV-2 research

    07 April 2021

    The SARS-CoV-2 coronavirus encodes a papain-like cysteine protease PLpro (NSP3) that cleaves the viral polyprotein, removes ubiquitin-like ISG15 protein modifications and (with lower activity) Lys48-linked polyubiquitin chains. As PLPro is essential for SARS-CoV-2 replication, it represents a promising target for the development of antiviral drugs. In light of this and to complement our well-known ubiquitin based reagents, we are expanding our portfolio of ISG15 based reagents.....(more)

     

     

  • UbiQ-news: Anti–COVID-19 Drug Design

    18 November 2020

    The global epidemic of three coronaviruses has emerged in this century so far: SARS-CoV-1 in 2002, MERS-CoV in 2012 and SARS-CoV-2 in 2019. Current studies indicate that SARS-CoV-2 is similar to SARS-CoV-1. Although these three coronaviruses are identified as highly pathogenic for humans, there is no effective antiviral treatment. Therefore, current studies are focused on rapid development of vaccines and antiviral drugs to prevent and treat coronavirus infection....(more)

     

     

  • UbiQ-news: Recent Scientific Accomplishments

    08 September 2020

    First of all, we wish all of our customers and partners well during this COVID-19 pandemic.
    Below we have listed some recent publications in which UbiQ participated and that might be of interest to you....(more)

     

     

  • In memoriam: Professor Huib Ovaa

    22 May 2020

    On the 19th of May 2020, our co-founder and dear friend Professor Dr. Huib Ovaa passed away from prostate cancer at the age of 46 years. In the past year, Huib has undergone a variety of treatments while continuing to do what he loved so much, being a scientist and mentor. We will miss him and always be grateful for his valuable contributions to our company and the ubiquitin field.
    Farid El Oualid and Alfred Nijkerk
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