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2nd Ubiquitin Function in Health and Disease Virtual Conference

By

Alfred Nijkerk

November 17 - 19, 2021

London, United Kingdom

Synopsis
We have reached a fascinating point in our research on the ubiquitin system’s function, physiology and roles in disease. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable degradation of proteins in the cytosol by the proteasome. It was much later that it was discovered that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives a multitude of signalling pathways the required plasticity to initiate but also to limit their signalling output in an exquisitely controlled manner. Whereas certain signalling-related functions employ ubiquitin’s proteasome-targeting function, e.g. the activation of NF-kB following degradation of I-kB, most signalling-related functions of the ubiquitin system are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.

Rather than discussing mainly structural aspects of the ubiquitin system, this virtual conference is dedicated to the study of functional roles of the ubiquitin system, how it works to ensure normal signal transduction, what are the pathological consequences when it is perturbed and how can we harness our knowledge of the ubiquitin system therapeutically for more efficacious treatment of diseases with high unmet clinical need, including cancer, chronic inflammatory and autoimmune disorders as well as neurodegenerative diseases.

Importantly, this virtual conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues that emerge from the study of the ubiquitin system will be presented and discussed.

Confirmed Plenary Speakers
Eric Baehrecke (UMass Medical School)
A NOVEL RELATIONSHIP BETWEEN UBIQUITIN, MITOCHONDRIA AND AUTOPHAGY
Ivan Dikic (Goethe University Frankfurt)
UBIQUITIN SYSTEM IN BACTERIAL INFECTIONS
Rachel Klevit (University of Washington)
BRCA1/BARD1, TWENTY YEARS LATER
Pascal Meier (ICR London)
UBIQUITIN-MEDIATED REGULATION OF NECROPTOSIS
Michele Pagano (NYU)
UNCOVERING THE POWER OF PROTEIN DEGRADATION: MECHANISMS TO THERAPEUTIC STRATEGIES
Simona Polo (IFOM)
RIBONUCLEOPROTEIN GRANULES IN NEURONS AND OVARIES: DYNAMIC SENSORS MODULATED BY UBIQUITIN
John Silke (The Walter and Eliza Hall Institute of Medical Research)
UBIQUITIN AND DEAD BODIES, A DEGRADING BUSINESS
Sylvie Urbe (University of Liverpool)
DEUBIQUITINASES (DUBS): DRUGGABLE REGULATORS OF PROTEIN AND ORGANELLE HOMEOSTASIS

Confirmed Invited Speakers
Tim Clausen (IMP)
THERE IS A MEG IN UBIQUITIN WATERS
Brian Ferguson (University of Cambridge)
ANTI-VIRAL FUNCTIONS OF LINEAR UBIQUITIN CHAINS
Thorsten Hoppe (CECAD)
ORGANISMAL REGULATION OF UBIQUITIN-MEDIATED QUALITY CONTROL
Kim Newton (Genentech)
REGULATION OF CELL DEATH AND INFLAMMATION BY DUBs OTULIN AND CYLD
Michal Sharon (Weizmann Institute of Science)
SPECIFIC REGULATION OF THE 20S PROTEASOME COMPLEX
Domagoj Vucic (Genentech)
UBIQUITINATION REGULATES INFLAMMATORY SIGNALING BY RIP KINASES

Contact: Farid El Oualid (CSO)

More info conference: https://online.fusion-conferences.com/all-conferences/6