20 February 2015
Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G.
Sahtoe et al., 2015, Molecular Cell 57, 1–14
Deubiquitinating enzyme UCH-L5 (UCH37) is involved in DNA repair and the proteasome system. Sahtoe et al. uncover how two evolutionarily related DEUBAD domains in RPN13 (ADRM1) and INO80G (NFRKB) can either activate or inhibit UCH-L5. These remarkable regulatory modes exploit flexible structural elements in UCH-L5 to modulate activity.