reagents

  • Biotin-Ahx-SUMO2-Dha

    UbiQ code: UbiQ-159

    Biotin-Ahx-SUMO2-Dha (Dha= dehydroalanine) is a new and first of its kind activity based probe for the SUMO ligation pathway. [

    crystallizationpull downpurificationwestern blotphenotypic protein profilingtarget inhibitor profiling
  • K63 diUb PA

    UbiQ code: UbiQ-114

    Potent, irreversible and specific inhibitor based on K63 linked diUb that targets the S2 pocket of deubiquitinating enzymes (DUBs). The C-terminus of the proximal Ub is equiped with the propargylamide (PA) electrophile and the isopeptide bond between the two Ub proteins is replaced by a DUB resistant mimic.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • SUMO1-Dha

    UbiQ code: UbiQ-116

    SUMO1-Dha is a new and first of its kind activity based probe for the SUMO ligation pathway.

    crystallizationwestern blot
  • SUMO2-Dha

    UbiQ code: UbiQ-117

    SUMO2-Dha is a new and first of its kind activity based probe for the SUMO ligation pathway.

    crystallizationwestern blot
  • SUMO3-Dha

    UbiQ code: UbiQ-118

    SUMO3-Dha is a new and first of its kind activity based probe for the SUMO ligation pathway.

    crystallizationwestern blot
  • Ub K48C

    UbiQ code: UbiQ-179

    UbiQ-179 consists of the ubiquitin protein (Ub) in which Lys48 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-Ub-VS

    UbiQ code: UbiQ-188

    Ubiquitin-Vinyl Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • HA-Ub-VS

    UbiQ code: UbiQ-187

    HA-Ubiquitin-Viny Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • Biotin-K63 diUb-VME

    UbiQ code: UbiQ-115

    UbiQ-115 (Biotin-Ahx-K63 diUbiquitin VME) probe is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K63 linked diUb. Here Lys63 has been replaced by a diaminobutyric acid residue equipped with a VME type warhead3.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • K382 Ub-p53(368-389)-FP

    UbiQ code: UbiQ-041

    UbiQ-041 (K382 Ub-p53(368-389)-FP) is a class II fluorescence polarization HTS reagent based on the C-terminal peptide sequence 368 – 389 of p53, which contains various lysine residues that are (mono)ubiquitinated.

    DUB activity profilingcompound library screening
  • K382 Ub-p53(357-389)-FP

    UbiQ code: UbiQ-042

    UbiQ-041 (K382 Ub-p53(368-389)-FP) is a class II fluorescence polarization HTS reagent based on the C-terminal peptide sequence 368 – 389 of p53, which contains various lysine residues that are (mono)ubiquitinated.

    DUB activity profilingcompound library screening
  • 5-TAMRA-Lys-Gly-OH

    UbiQ code: UbiQ-023

    UbiQ-023 is a fluorescence polarization HTS control reagent that can be used to make a concentration calibration curve and determine the grating factor (G).

    compound library screening
  • His10-SUMO3-Dha

    UbiQ code: UbiQ-124

    His10-SUMO3-Dha is a new and first of its kind activity based probe for the SUMO ligation pathway.

    crystallizationwestern blot
  • His6-3C-MAP1LC3a-Dha

    UbiQ code: UbiQ-158

    UbiQ-158 is an activity-based probe for E1 activating enzymes and E2 conjugating enzymes that are involved in autophagy (e.g. ATG7 and ATG3, respectively). The N-terminus is labeled with an His6 affinity tag and a 3C protease cleavage site (QG), Cys17 has been mutated to a Ser residue (S).

    crystallizationwestern blot
  • Biotin-Ahx-SUMO2-VME

    UbiQ code: UbiQ-156

    Biotin-Ahx-SUMO2-VME is an activity-based probe for SUMO proteases.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling

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