reagents

  • Biotin-K63 diUb-VME

    UbiQ code: UbiQ-115

    UbiQ-115 (Biotin-Ahx-K63 diUbiquitin VME) probe is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K63 linked diUb. Here Lys63 has been replaced by a diaminobutyric acid residue equipped with a VME type warhead3.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Biotin-Ahx-Ub pThr12

    UbiQ code: UbiQ-093

    UbiQ-093 is ubiquitin that is phosphorylated on Thr12.

    pull downpurificationphenotypic protein profilingcompound library screening
  • Ub-VME

    UbiQ code: UbiQ-005

    Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-Ub-VS

    UbiQ code: UbiQ-188

    Ubiquitin-Vinyl Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • Biotin-Ahx-Ub pThr7

    UbiQ code: UbiQ-092

    UbiQ-092 is a ubiquitin protein that is phosphorylated on Thr7. Phosphoproteomic studies have identified several phosphorylated sites in ubiquitin, among them pThr7.

    pull downpurificationphenotypic protein profilingcompound library screening
  • Ub pSer57

    UbiQ code: UbiQ-113

    UbiQ-113 is ubiquitin that is phosphorylated on Ser57.

    pull downpurificationphenotypic protein profilingcompound library screening
  • Biotin-Ahx-SUMO2-Dha

    UbiQ code: UbiQ-159

    Biotin-Ahx-SUMO2-Dha (Dha= dehydroalanine) is a new and first of its kind activity based probe for the SUMO ligation pathway. [

    crystallizationpull downpurificationwestern blotphenotypic protein profilingtarget inhibitor profiling
  • Biotin-Ahx-SUMO2-VME

    UbiQ code: UbiQ-156

    Biotin-Ahx-SUMO2-VME is an activity-based probe for SUMO proteases.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • Biotin-Ahx-Ub pSer 57

    UbiQ code: UbiQ-094

    UbiQ-094 is ubiquitin that is phosphorylated on Ser57.

    pull downpurificationphenotypic protein profilingcompound library screening
  • HA-Ahx-Ahx-Ub-VS

    UbiQ code: UbiQ-187

    HA-Ahx-Ahx-Ubiquitin-Viny Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • Biotin-Ahx-Ub pSer 65

    UbiQ code: UbiQ-091

    UbiQ-091 is ubiquitin that is phosphorylated on Ser65, a ubiquitin variant which has been shown to activate Parkin E3 ligase mediated ubiquitination.

    pull downpurificationphenotypic protein profilingcompound library screening
  • Ub-PA

    UbiQ code: UbiQ-057

    Ubiquitin-propargylamide is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • K63 diUb PA

    UbiQ code: UbiQ-114

    Potent, irreversible and specific inhibitor based on K63 linked diUb that targets the S2 pocket of deubiquitinating enzymes (DUBs). The C-terminus of the proximal Ub is equiped with the propargylamide (PA) electrophile and the isopeptide bond between the two Ub proteins is replaced by a DUB resistant mimic.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Biotin-ANP-Ub-PA

    UbiQ code: UbiQ-077

    Biotin-ANP-Ub-PA (UbiQ-077) is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs). It is labeled on the N-terminus with biotin and contains the UV cleavable 3-amino-3-(2-nitrophenyl)propanoic acid (ANP) linker, allowing for UV mediated cleavage of the biotin tag.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • Biotin-Ahx-Ub pTyr59

    UbiQ code: UbiQ-095

    UbiQ-095 is ubiquitin that is phosphorylated on Tyr59.

    pull downpurificationphenotypic protein profilingcompound library screening

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