reagents

  • K63 diUb PA

    UbiQ code: UbiQ-114

    Potent, irreversible and specific inhibitor based on K63 linked diUb that targets the S2 pocket of deubiquitinating enzymes (DUBs). The C-terminus of the proximal Ub is equiped with the propargylamide (PA) electrophile and the isopeptide bond between the two Ub proteins is replaced by a DUB resistant mimic.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Ub-PA

    UbiQ code: UbiQ-057

    Ubiquitin-propargylamide is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • Biotin-K63 diUb-VME

    UbiQ code: UbiQ-115

    UbiQ-115 (Biotin-Ahx-K63 diUbiquitin VME) probe is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K63 linked diUb. Here Lys63 has been replaced by a diaminobutyric acid residue equipped with a VME type warhead3.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Biotin-Ahx-Ub-VS

    UbiQ code: UbiQ-188

    Biotin-Ahx-Ub-VS (UbiQ-188) is a potent and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic vinyl sulfone (VS) group.

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • Ub-VME

    UbiQ code: UbiQ-005

    Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-ANP-Ub-PA

    UbiQ code: UbiQ-077

    Biotin-ANP-Ub-PA (UbiQ-077) is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs). It is labeled on the N-terminus with biotin and contains the UV cleavable 3-amino-3-(2-nitrophenyl)propanoic acid (ANP) linker, allowing for UV mediated cleavage of the biotin tag.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • HA-Ahx-Ahx-Ub-VS

    UbiQ code: UbiQ-187

    HA-Ahx-Ahx-Ubiquitin-Viny Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • DUB activity based probe explorer panel

    UbiQ code: UbiQ-L02

    UbiQ-L02 is a panel of the following 10 deubiquitylating enzyme (DUB) activity based probes (ABPs).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • custom assay reagents

    UbiQ code: UbiQ-C01 ref PO

    Ubiquitin(-like) (e.g. Ub, Nedd8, SUMO, etc.) assay reagents with various modifications (unnatural amino acids, peptides, tags, etc.)

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • di-ubiquitin activity based probe explorer panel

    UbiQ code: UbiQ-L04

    UbiQ-L04 contains seven deubiquitylating enzymes (DUB) activity-based probes based on K6, 11, 27, 29, 33, 48, and 63 linked diUb.

    crystallizationpurification
  • Ub-VS

    UbiQ code: UbiQ-108

    Ubiquitin-Viny Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • HA-Ahx-Ahx-Ub-VME

    UbiQ code: UbiQ-035

    UbiQ-035 (Ub-VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs), which is N-terminally tagged with an HA-tag.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • HA-Ahx-Ahx-Ub-PA

    UbiQ code: UbiQ-078

    This probe is a potent and specific inhibitor of deubiquitylating enzymes (DUBs) containing the propargylamide (PA) warhead.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Biotin-Ahx-Ub-PA

    UbiQ code: UbiQ-076

    Biotin-Ahx-Ub-PA (UbiQ-076) is a potent and specific inhibitor of deubiquitylating enzymes (DUBs), which is labeled on the N-terminus with biotin and contains a C-terminal propargylamide (PA) electrophile.

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • Biotin-Ahx-Ub-VME

    UbiQ code: UbiQ-054

    UbiQ-054 (Biotin-Ahx-Ub-VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs), which is labeled on the N-terminus with biotin.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling

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