reagents

  • Biotin-K63 diUb-VME

    UbiQ code: UbiQ-115

    UbiQ-115 (Biotin-Ahx-K63 diUbiquitin VME) probe is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K63 linked diUb. Here Lys63 has been replaced by a diaminobutyric acid residue equipped with a VME type warhead3.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Ub-PA

    UbiQ code: UbiQ-057

    Ubiquitin-propargylamide is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • Biotin-ANP-Ub-PA

    UbiQ code: UbiQ-077

    Biotin-ANP-Ub-PA (UbiQ-077) is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs). It is labeled on the N-terminus with biotin and contains the UV cleavable 3-amino-3-(2-nitrophenyl)propanoic acid (ANP) linker, allowing for UV mediated cleavage of the biotin tag.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • K63 diUb PA

    UbiQ code: UbiQ-114

    Potent, irreversible and specific inhibitor based on K63 linked diUb that targets the S2 pocket of deubiquitinating enzymes (DUBs). The C-terminus of the proximal Ub is equiped with the propargylamide (PA) electrophile and the isopeptide bond between the two Ub proteins is replaced by a DUB resistant mimic.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Ub-VME

    UbiQ code: UbiQ-005

    Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub photoLeu73

    UbiQ code: UbiQ-154

    UbiQ-154 is a new crosslinking reagent based on ubiquitin in which Leu73 is replaced by the photoreactive analog photoleucine (photoLeu).

    crystallizationpull downwestern blotMS
  • DUB activity based probe explorer panel

    UbiQ code: UbiQ-L02

    UbiQ-L02 is a panel of the following 10 deubiquitylating enzyme (DUB) activity based probes (ABPs).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • custom assay reagents

    UbiQ code: UbiQ-C01 ref PO

    Ubiquitin(-like) (e.g. Ub, Nedd8, SUMO, etc.) assay reagents with various modifications (unnatural amino acids, peptides, tags, etc.)

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • HA-Ahx-Ahx-Ub-PA

    UbiQ code: UbiQ-078

    This probe is a potent and specific inhibitor of deubiquitylating enzymes (DUBs) containing the propargylamide (PA) warhead.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • HA-Ahx-Ahx-Ub-VME

    UbiQ code: UbiQ-035

    UbiQ-035 (Ub-VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs), which is N-terminally tagged with an HA-tag.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Biotin-Ahx-Ub-VME

    UbiQ code: UbiQ-054

    UbiQ-054 (Biotin-Ahx-Ub-VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs), which is labeled on the N-terminus with biotin.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Biotin-Ahx-Ub-PA

    UbiQ code: UbiQ-076

    Biotin-Ahx-Ub-PA (UbiQ-076) is a potent and specific inhibitor of deubiquitylating enzymes (DUBs), which is labeled on the N-terminus with biotin and contains a C-terminal propargylamide (PA) electrophile.

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • TAMRA-Ub-PA

    UbiQ code: UbiQ-058

    TAMRA-Ub-PA is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs), labeled with a 5-carboxytetramethylrhodamine (TAMRA) dye on the N-terminus.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • TAMRA-Ub-VME

    UbiQ code: UbiQ-050

    TAMRA-Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs), which is labeled on the N-terminus with a 5-carboxytetramethylrhodamine (TAMRA) dye.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • Cy5-Ub-PA

    UbiQ code: UbiQ-072

    Cy5-Ub-PA is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs), labeled with a Cy5 dye on the N-terminus.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling

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