reagents

  • Ub K6C

    UbiQ code: UbiQ-174

    UbiQ-174 consists of the ubiquitin protein (Ub) in which Lys6 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K63C

    UbiQ code: UbiQ-180

    UbiQ-180 consists of the ubiquitin protein (Ub) in which Lys63 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K48C

    UbiQ code: UbiQ-179

    UbiQ-179 consists of the ubiquitin protein (Ub) in which Lys48 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-Ahx-SUMO2-VME

    UbiQ code: UbiQ-156

    Biotin-Ahx-SUMO2-VME is an activity-based probe for SUMO proteases.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • Ub K29C

    UbiQ code: UbiQ-177

    UbiQ-177 consists of the ubiquitin protein (Ub) in which Lys29 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • His6-Ahx-Ahx-SUMO2-VPS

    UbiQ code: UbiQ-237

    His6-Ahx-Ahx-SUMO2-VPS (UbiQ-237) is an activity-based probe for SUMO proteases.

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • K382 Ub-p53(368-389)-FP

    UbiQ code: UbiQ-041

    UbiQ-041 (K382 Ub-p53(368-389)-FP) is a class II fluorescence polarization HTS reagent based on the C-terminal peptide sequence 368 – 389 of p53, which contains various lysine residues that are (mono)ubiquitinated.

    DUB activity profilingcompound library screening
  • Ub K11C

    UbiQ code: UbiQ-175

    UbiQ-175 consists of the ubiquitin protein (Ub) in which Lys11 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub-VME

    UbiQ code: UbiQ-005

    Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-Ahx-Ub-VS

    UbiQ code: UbiQ-188

    Biotin-Ahx-Ub-VS (UbiQ-188) is a potent and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic vinyl sulfone (VS) group.

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • Biotin-ANP-Ub-PA

    UbiQ code: UbiQ-077

    Biotin-ANP-Ub-PA (UbiQ-077) is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs). It is labeled on the N-terminus with biotin and contains the UV cleavable 3-amino-3-(2-nitrophenyl)propanoic acid (ANP) linker, allowing for UV mediated cleavage of the biotin tag.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • Ub K33C

    UbiQ code: UbiQ-178

    UbiQ-178 consists of the ubiquitin protein (Ub) in which Lys33 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • K382 Ub-p53(357-389)-FP

    UbiQ code: UbiQ-042

    UbiQ-041 (K382 Ub-p53(368-389)-FP) is a class II fluorescence polarization HTS reagent based on the C-terminal peptide sequence 368 – 389 of p53, which contains various lysine residues that are (mono)ubiquitinated.

    DUB activity profilingcompound library screening
  • Ub K27C

    UbiQ code: UbiQ-176

    UbiQ-176 consists of the ubiquitin protein (Ub) in which Lys27 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • HA-Ahx-Ahx-Ub-VPS

    UbiQ code: UbiQ-193

    HA-Ahx-Ahx-Ub-VPS (UbiQ-193) is an activity-based probe and inhibitor of DUBs.

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling

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