reagents

Biotin-Ahx-SUMO2-Dha (Dha= dehydroalanine) is a new and first of its kind activity based probe for the SUMO ligation pathway. [

human SUMO2 sequence (C48S) which is functionalized on the N-terminus with a 5-carboxyrhodamine110 dye.

Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

Ubiquitin(-like) (e.g. Ub, Nedd8, SUMO, etc.) assay reagents with various modifications (unnatural amino acids, peptides, tags, etc.)

Cy5-Ub-Dha is a new activity based probe for Ub E1, E2 and (HECT/RBR) E3 ligases. The N-terminus of UbiQ-104 is labeled with a Cy5 tag.

UbiQ-103 is a new activity based probe for Ub E1, E2 and (HECT/RBR) E3 ligases. The N-terminus of UbiQ-103 is labeled with an His6 tag; two aminohexanoic acid (Ahx) linkers are used to create extra space between the His6 and Ub protein for efficient access of His6 binding entities.

Biotin-Ahx-Ub-Dha is a new activity based probe for Ub E1, E2 and (HECT/RBR) E3 ligases including a biotin tag.

5-carboxyRh110-Ub-Dha is a new activity based probe for Ub E1, E2 and (HECT/RBR) E3 ligases.

Biotin-Ahx-Nedd8-Dha is a new activity based probe for Nedd8 E1, E2 and (HECT/RBR) E3 ligases.

5-carboxyRh110-Nedd8-Dha is a new activity based probe for Ub E1, E2 and (HECT/RBR) E3 ligases. The N-terminus of UbiQ-122 is labeled with the green fluorescent 5-carboxyrhodamine110 dye (cRh110).

Custom ubiquitin(-like) probes with various C-terminal warheads (e.g. VME= vinylmethyl ester, PA = propagylamide, VS= vinyl sulfone, Dha= dehydroalanine) and N-terminal tags (e.g. TAMRA, Cy5, biotin).

Our UbiQ-PEP™ service provides isopeptide linked Ub-polypeptide conjugates with a range of modifications to meet your research needs.