reagents

  • hISG15-FP

    UbiQ code: UbiQ-287

    UbiQ-287 is a fluorescence polarization assay reagent for deISGylating enzymes which is based on a 5-carboxytetramethylrhodamine (TAMRA, exc 550 nm, emi 590 nm) modified Lys-Gly sequence that is linked to human ISG15 via a native isopeptide bond.

    DUB activity profilingcompound library screening
  • 5-TAMRA-Lys-Gly-OH

    UbiQ code: UbiQ-023

    UbiQ-023 is a fluorescence polarization HTS control reagent that can be used to make a concentration calibration curve and determine the grating factor (G).

    compound library screening
  • Ub K33C

    UbiQ code: UbiQ-178

    UbiQ-178 consists of the ubiquitin protein (Ub) in which Lys33 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-Ahx-Ub pSer 57

    UbiQ code: UbiQ-094

    UbiQ-094 is ubiquitin that is phosphorylated on Ser57.

    pull downpurificationphenotypic protein profilingcompound library screening
  • His6-Ahx-Ahx-SUMO2-VPS

    UbiQ code: UbiQ-237

    His6-Ahx-Ahx-SUMO2-VPS (UbiQ-237) is an activity-based probe for SUMO proteases.

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • K382 Ub-p53(368-389)-FP

    UbiQ code: UbiQ-041

    UbiQ-041 (K382 Ub-p53(368-389)-FP) is a class II fluorescence polarization HTS reagent based on the C-terminal peptide sequence 368 – 389 of p53, which contains various lysine residues that are (mono)ubiquitinated.

    DUB activity profilingcompound library screening
  • Ub K27C

    UbiQ code: UbiQ-176

    UbiQ-176 consists of the ubiquitin protein (Ub) in which Lys27 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-Ahx-Ub pSer 65

    UbiQ code: UbiQ-091

    UbiQ-091 is ubiquitin that is phosphorylated on Ser65, a ubiquitin variant which has been shown to activate Parkin E3 ligase mediated ubiquitination.

    pull downpurificationphenotypic protein profilingcompound library screening
  • Ub-VME

    UbiQ code: UbiQ-005

    Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K6C

    UbiQ code: UbiQ-174

    UbiQ-174 consists of the ubiquitin protein (Ub) in which Lys6 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K63C

    UbiQ code: UbiQ-180

    UbiQ-180 consists of the ubiquitin protein (Ub) in which Lys63 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-Ahx-Ub pTyr59

    UbiQ code: UbiQ-095

    UbiQ-095 is ubiquitin that is phosphorylated on Tyr59.

    pull downpurificationphenotypic protein profilingcompound library screening
  • Ac-ISG15prox-VPS

    UbiQ code: UbiQ-262

    UbiQ-262 is an activity-based probe for and inhibitor of ISG15 proteases.

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • K382 Ub-p53(357-389)-FP

    UbiQ code: UbiQ-042

    UbiQ-041 (K382 Ub-p53(368-389)-FP) is a class II fluorescence polarization HTS reagent based on the C-terminal peptide sequence 368 – 389 of p53, which contains various lysine residues that are (mono)ubiquitinated.

    DUB activity profilingcompound library screening
  • Ub K29C

    UbiQ code: UbiQ-177

    UbiQ-177 consists of the ubiquitin protein (Ub) in which Lys29 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling

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