reagents
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Ub-VME
UbiQ code: UbiQ-005Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),
crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling -
custom assay reagents
UbiQ code: UbiQ-C01 ref POUbiquitin(-like) (e.g. Ub, Nedd8, SUMO, etc.) assay reagents with various modifications (unnatural amino acids, peptides, tags, etc.)
crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling -
5-carboxyRh110-Ub-Dha
UbiQ code: UbiQ-1315-carboxyRh110-Ub-Dha is a new activity based probe for Ub E1, E2 and (HECT/RBR) E3 ligases.
phenotypic protein profilingcompound library screeningtarget inhibitor profiling -
Cy5-Ub-Dha
UbiQ code: UbiQ-104Cy5-Ub-Dha is a new activity based probe for Ub E1, E2 and (HECT/RBR) E3 ligases. The N-terminus of UbiQ-104 is labeled with a Cy5 tag.
phenotypic protein profilingcompound library screeningtarget inhibitor profiling -
5-carboxyRh110-Nedd8-Dha
UbiQ code: UbiQ-1225-carboxyRh110-Nedd8-Dha is a new activity based probe for Ub E1, E2 and (HECT/RBR) E3 ligases. The N-terminus of UbiQ-122 is labeled with the green fluorescent 5-carboxyrhodamine110 dye (cRh110).
phenotypic protein profilingcompound library screeningtarget inhibitor profiling -
custom probes
UbiQ code: UbiQ-C02Custom ubiquitin(-like) probes with various C-terminal warheads (e.g. VME= vinylmethyl ester, PA = propagylamide, VS= vinyl sulfone, Dha= dehydroalanine) and N-terminal tags (e.g. TAMRA, Cy5, biotin).
crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling -
custom peptides
UbiQ code: UbiQ-C03Our UbiQ-PEP™ service provides isopeptide linked Ub-polypeptide conjugates with a range of modifications to meet your research needs.
crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling