reagents

HA-Ahx-Ahx-Ub-VPS (UbiQ-193) is an activity-based probe and inhibitor of DUBs.

Ubiquitin-propargylamide is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs).

His6-Ahx-Ahx-SUMO2-VPS (UbiQ-237) is an activity-based probe for SUMO proteases.

Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

UbiQ-262 is an activity-based probe for and inhibitor of ISG15 proteases

UbiQ-L02 is a panel of 10 deubiquitinating enzyme (DUB) activity-based probes (ABPs).

Ubiquitin(-like) (e.g. Ub, Nedd8, SUMO, etc.) assay reagents with various modifications (unnatural amino acids, peptides, tags, etc.)

Biotin-Ahx-Ub-PA (UbiQ-076) is a potent and specific inhibitor of deubiquitylating enzymes (DUBs), which is labeled on the N-terminus with biotin and contains a C-terminal propargylamide (PA) electrophile.

UbiQ-083 (K27 linked diUbiquitin VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K27 linked diUb.

UbiQ-085 (K33 linked diUbiquitin VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K33 linked diUb.

UbiQ-081 (K6 linked di-Ubiquitin VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K6 linked diUb.

UbiQ-121 is an activity based probe designed specifically to target deubiquitylating enzymes (DUBs) that recognize linear Ub-chains. The Gly-Met dipeptide between the two Ub proteins of a linear diUb has been replaced by a dehydroalanine-Met (Dha-Met) dipeptide, which reacts with OTULIN in a covalent manner.

UbiQ-086 (K48 diUbiquitin VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K48 linked diUb.

Custom ubiquitin(-like) probes with various C-terminal warheads (e.g. VME= vinylmethyl ester, PA = propagylamide, VS= vinyl sulfone, Dha= dehydroalanine) and N-terminal tags (e.g. TAMRA, Cy5, biotin).

Our UbiQ-PEP™ service provides isopeptide linked Ub-polypeptide conjugates with a range of modifications to meet your research needs.