reagents

  • DUB activity based probe explorer panel

    UbiQ code: UbiQ-L02

    UbiQ-L02 is a panel of the following 10 deubiquitylating enzyme (DUB) activity based probes (ABPs).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • di-ubiquitin activity based probe explorer panel

    UbiQ code: UbiQ-L04

    UbiQ-L04 contains seven deubiquitylating enzymes (DUB) activity-based probes based on K6, 11, 27, 29, 33, 48, and 63 linked diUb.

    crystallizationpurification
  • Biotin-ANP-Ub-PA

    UbiQ code: UbiQ-077

    Biotin-ANP-Ub-PA (UbiQ-077) is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs). It is labeled on the N-terminus with biotin and contains the UV cleavable 3-amino-3-(2-nitrophenyl)propanoic acid (ANP) linker, allowing for UV mediated cleavage of the biotin tag.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • Biotin-Ahx-SUMO2-VME

    UbiQ code: UbiQ-156

    Biotin-Ahx-SUMO2-VME is an activity-based probe for SUMO proteases.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • His6-3C-MAP1LC3a-Dha

    UbiQ code: UbiQ-158

    UbiQ-158 is an activity-based probe for E1 activating enzymes and E2 conjugating enzymes that are involved in autophagy (e.g. ATG7 and ATG3, respectively). The N-terminus is labeled with an His6 affinity tag and a 3C protease cleavage site (QG), Cys17 has been mutated to a Ser residue (S).

    crystallizationwestern blot
  • His10-SUMO3-Dha

    UbiQ code: UbiQ-124

    His10-SUMO3-Dha is a new and first of its kind activity based probe for the SUMO ligation pathway.

    crystallizationwestern blot
  • Biotin-K63 diUb-VME

    UbiQ code: UbiQ-115

    UbiQ-115 (Biotin-Ahx-K63 diUbiquitin VME) probe is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K63 linked diUb. Here Lys63 has been replaced by a diaminobutyric acid residue equipped with a VME type warhead3.

    crystallizationpull downpurificationwestern blotphenotypic protein profiling
  • HA-Ahx-Ahx-Ub-VS

    UbiQ code: UbiQ-187

    HA-Ahx-Ahx-Ubiquitin-Viny Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • Biotin-Ub-VS

    UbiQ code: UbiQ-188

    Ubiquitin-Vinyl Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • SUMO3-Dha

    UbiQ code: UbiQ-118

    SUMO3-Dha is a new and first of its kind activity based probe for the SUMO ligation pathway.

    crystallizationwestern blot
  • SUMO2-Dha

    UbiQ code: UbiQ-117

    SUMO2-Dha is a new and first of its kind activity based probe for the SUMO ligation pathway.

    crystallizationwestern blot
  • Ub-VS

    UbiQ code: UbiQ-108

    Ubiquitin-Viny Sulfone is an inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpurificationwestern blotphenotypic protein profilingDUB activity profiling
  • Ub-VME

    UbiQ code: UbiQ-005

    Ubiquitin with a vinyl methyl ester (VME) warhead is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • Ub-PA

    UbiQ code: UbiQ-057

    Ubiquitin-Propargylamide is a newly developed potent and specific inhibitor of deubiquitylating enzymes (DUBs).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling
  • Biotin-Ahx-SUMO2-Dha

    UbiQ code: UbiQ-159

    Biotin-Ahx-SUMO2-Dha (Dha= dehydroalanine) is a new and first of its kind activity based probe for the SUMO ligation pathway. [

    crystallizationpull downpurificationwestern blotphenotypic protein profilingtarget inhibitor profiling

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