reagents

  • DUB assay explorer panel

    UbiQ code: UbiQ-L03

    UbiQ-L03 is a panel of 4 deubiquitylating enzyme (DUB) activity assay reagents (25 ug each) prepared by total chemical synthesis.

    DUB activity profilingcompound library screening
  • customized assay reagents

    UbiQ code: UbiQ-C01 ref PO

    Ubiquitin(-like) (e.g. Ub, Nedd8, SUMO, etc.) assay reagents with various modifications (unnatural amino acids, peptides, tags, etc.)

    DUB activity profilingcompound library screening
  • Ub photoLeu73

    UbiQ code: UbiQ-154

    UbiQ-154 is a new crosslinking reagent based on ubiquitin in which Leu73 is replaced by the photoreactive analog photoleucine (photoLeu).

    crystallizationpull downwestern blotMS
  • Ub K63C

    UbiQ code: UbiQ-180

    UbiQ-180 consists of the ubiquitin protein (Ub) in which Lys63 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K33C

    UbiQ code: UbiQ-178

    UbiQ-178 consists of the ubiquitin protein (Ub) in which Lys33 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K29C

    UbiQ code: UbiQ-177

    UbiQ-177 consists of the ubiquitin protein (Ub) in which Lys29 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K27C

    UbiQ code: UbiQ-176

    UbiQ-176 consists of the ubiquitin protein (Ub) in which Lys27 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K11C

    UbiQ code: UbiQ-175

    UbiQ-175 consists of the ubiquitin protein (Ub) in which Lys11 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • Ub K6C

    UbiQ code: UbiQ-174

    UbiQ-174 consists of the ubiquitin protein (Ub) in which Lys6 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • 5-carboxyRh110-SUMO2

    UbiQ code: UbiQ-134

    human SUMO2 sequence (C48S) which is functionalized on the N-terminus with a 5-carboxyrhodamine110 dye.

    crystallizationMSphenotypic protein profilingtarget inhibitor profiling
  • Mca-KKVAPYPME-Dap(Dnp)–NH2 | proteasome activity assay reagent

    UbiQ code: UbiQ-141

    LF2 peptide based fluorogenic proteasome assay reagent for monitoring 26S proteasome, or ClpP protease activity.

  • Ub K48C

    UbiQ code: UbiQ-179

    UbiQ-179 consists of the ubiquitin protein (Ub) in which Lys48 has been mutated to a cysteine residue.

    DUB activity profilingcompound library screeningtarget inhibitor profiling
  • K382 Ub-p53(368-389)-FP

    UbiQ code: UbiQ-041

    UbiQ-041 (K382 Ub-p53(368-389)-FP) is a class II fluorescence polarization HTS reagent based on the C-terminal peptide sequence 368 – 389 of p53, which contains various lysine residues that are (mono)ubiquitinated.

    DUB activity profilingcompound library screening
  • K382 Ub-p53(357-389)-FP

    UbiQ code: UbiQ-042

    UbiQ-041 (K382 Ub-p53(368-389)-FP) is a class II fluorescence polarization HTS reagent based on the C-terminal peptide sequence 368 – 389 of p53, which contains various lysine residues that are (mono)ubiquitinated.

    DUB activity profilingcompound library screening
  • 5-TAMRA-Lys-Gly-OH

    UbiQ code: UbiQ-023

    UbiQ-023 is a fluorescence polarization HTS control reagent that can be used to make a concentration calibration curve and determine the grating factor (G).

    compound library screening

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