reagents

UbiQ-287 is a fluorescence polarization assay reagent for deISGylating enzymes which is based on a 5-carboxytetramethylrhodamine (TAMRA, exc 550 nm, emi 590 nm) modified Lys-Gly sequence that is linked to human ISG15 via a native isopeptide bond.

Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

UbiQ-262 is an activity-based probe for and inhibitor of ISG15 proteases.

Ac-ISG15prox-Rh110MP (UbiQ-127) is a new type of quenched, fluorescent substrate for ISG15 proteases based on the proximal part of (mouse) ISG15 (aa 77-165).

Ubiquitin(-like) (e.g. Ub, Nedd8, SUMO, etc.) assay reagents with various modifications (unnatural amino acids, peptides, tags, etc.)

Custom ubiquitin(-like) probes with various C-terminal warheads (e.g. VME= vinylmethyl ester, PA = propagylamide, VS= vinyl sulfone, Dha= dehydroalanine) and N-terminal tags (e.g. TAMRA, Cy5, biotin).

Our UbiQ-PEP™ service provides isopeptide linked Ub-polypeptide conjugates with a range of modifications to meet your research needs.