reagents

  • Ub-VME

    UbiQ code: UbiQ-005

    Ub-VME is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs),

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • Biotin-Ahx-SUMO2-VME

    UbiQ code: UbiQ-156

    Biotin-Ahx-SUMO2-VME is an activity-based probe for SUMO proteases.

    crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling
  • NEDD8-FP

    UbiQ code: UbiQ-019

    Nedd8-FP (UbiQ-019) is a fluorescence polarization assay reagent which is based on a 5-carboxytetramethylrhodamine (TAMRA) modified Lys-Gly sequence that is linked to Nedd8 via a native isopeptide bond with the lysine side-chain.

    DUB activity profilingcompound library screening
  • SUMO3-FP

    UbiQ code: UbiQ-022

    SUMO3-FP (UbiQ-022) is a fluorescence polarization assay reagent for de-SUMOylating enzyme, based on a 5-carboxytetramethylrhodamine (TAMRA) modified Lys-Gly sequence that is linked to (6His tagged) SUMO-2 via a native isopeptide bond with the lysine side-chain.

    DUB activity profilingcompound library screening
  • SUMO1-FP

    UbiQ code: UbiQ-020

    SUMO1-FP (UbiQ-020) is a fluorescence polarization assay reagent for de-SUMOylating enzyme, based on a 5-carboxytetramethylrhodamine (TAMRA) modified Lys-Gly sequence that is linked to (6His tagged) SUMO-1 via a native isopeptide bond with the lysine side-chain.

    DUB activity profilingcompound library screening
  • ISG15-FP

    UbiQ code: UbiQ-073

    ISG15-FP (UbiQ-073) is a fluorescence polarization assay reagent for deISGylating enzymes which is based on a 5-carboxytetramethylrhodamine (TAMRA) modified Lys-Gly sequence that is linked to (mouse) ISG15 via a native isopeptide bond with the lysine side-chain.

    DUB activity profilingcompound library screening
  • SUMO2-FP

    UbiQ code: UbiQ-021

    SUMO2-FP (UbiQ-021) is a fluorescence polarization assay reagent for de-SUMOylating enzyme, based on a 5-carboxytetramethylrhodamine (TAMRA) modified Lys-Gly sequence that is linked to (6His tagged) SUMO-2 via a native isopeptide bond with the lysine side-chain.

    DUB activity profilingcompound library screening
  • K720 Nedd8-cullin1 (711-730)-FP

    UbiQ code: UbiQ-080

    Class II fluorescence polarization HTS reagent based on the cullin-1 (711-730) polypeptide

    DUB activity profilingcompound library screening
  • custom assay reagents

    UbiQ code: UbiQ-C01 ref PO

    Ubiquitin(-like) (e.g. Ub, Nedd8, SUMO, etc.) assay reagents with various modifications (unnatural amino acids, peptides, tags, etc.)

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • custom probes

    UbiQ code: UbiQ-C02

    Custom ubiquitin(-like) probes with various C-terminal warheads (e.g. VME= vinylmethyl ester, PA = propagylamide, VS= vinyl sulfone, Dha= dehydroalanine) and N-terminal tags (e.g. TAMRA, Cy5, biotin).

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling
  • custom peptides

    UbiQ code: UbiQ-C03

    Our UbiQ-PEP™ service provides isopeptide linked Ub-polypeptide conjugates with a range of modifications to meet your research needs.

    crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling

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