Ub-VME (UbiQ-005) is a potent, irreversible and specific inhibitor of deubiquitinating enzymes (DUBs). It inhibits the hydrolysis of poly-ubiquitin chains on substrate proteins in vitro and thus enhances poly-Ub chain accumulation. UbiQ-005 functions as an activity-based DUB probe.

Product Attachments

View FileUbiQ-005 Productsheet B01092012-001
crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profilingDUB activity profilingcompound library screeningtarget inhibitor profiling

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name Ub-VME
product code UbiQ-005
Applications crystallization, pull down, purification, western blot, MS, NMR, phenotypic protein profiling, DUB activity profiling, compound library screening, target inhibitor profiling
target DUB, Nedd8, SUMO 1,2,3, ISG15, Ubl proteases, E1/E2/E3, Proteasome
source human sequence, synthetic
shipping lyophilized powder
purity ≥95% by RP-HPLC
molecular weight 8.61 kDa
storage upon arrival, powder at −20°C and solution at −80°C. Please avoid multiple freeze/thaw cycles.
sample preparation For detailed sample preparation see product sheet.
regulatory statement For laboratory research use only, not for use in humans.