H2B (113-125) K120 Ub

H2B (113-125) K120 Ub

details

UbiQ-062 is an H2B(113-125) peptide which is monoubiquitinated at K120 via a native isopeptide bond. It can be used as a substrate for ubiquitin proteases, to investigate mechanism of binding and recognition by proteins that contain ubiquitin-associated domains or ubiquitin-interacting motifs (UIMs) and as antigen for immunizations.

Product Attachments

View FileUbiQ-062 Productsheet B01032014-001
pull downwestern blotMStarget inhibitor profiling

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mg
name H2B (113-125) K120 Ub
product code UbiQ-062
Applications pull down, western blot, MS, target inhibitor profiling
target DUB
source human sequence, synthetic
shipping lyophilized powder
purity ≥95% by SDS-PAGE analysis
molecular weight 9.95 kDa
storage upon arrival powder at −20°C, solution at −80°C. Please avoid multiple freeze/thaw cycles.
sample preparation For detailed sample preparation see product sheet.
regulatory statement For laboratory research use only, not for use in humans.
  • F. El Oualid et al.

    El Oualid, F., et al. Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin. Angewandte Chemie Int. Ed. 49, 10149-10153 (2010).

    http://www.ncbi.nlm.nih.gov/pubmed/21117055

  • Faesen et al.

    Faesen, A.C., et al. The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types. Chem. Biol. 18, 1550-1561 (2011). 

    http://www.ncbi.nlm.nih.gov/pubmed/22195557 

  • I. Dikic et al.

    Dikic, I., et al. Ubiquitin-binding domains - from structures to functions. Nat. Rev. Mol. Cell. Biol. 10, 659-671 (2010). 

    http://www.ncbi.nlm.nih.gov/pubmed/19773779

  • J. D. F. Licchesi et al.

    Licchesi, J.D., et al. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. Nat. Struct. Mol. Biol. 19, 62-71 (2012). 

    http://www.ncbi.nlm.nih.gov/pubmed/22157957

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