K48 diUb-VME

K48 diUb-VME


UbiQ-086 (K48 diUbiquitin VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K48 linked diUb. This DUB activity based probe can be used for activity profiling experiments and structural studies. Lys48 has been replaced by a diaminobutyric acid(vinylamide) residue as reactive mimic of the native isopeptidic linked Lys(Gly) residue. Please note the native distance between the proximal and distal Ubiquitin is preserved as much as possible in our diUbiquitin probe.

Product Attachments

View FileUbiQ-086 Productsheet B01112014-001
crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling

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name K48 diUb-VME
product code UbiQ-086
Applications crystallization, pull down, purification, western blot, MS, NMR, phenotypic protein profiling
target DUB
source human, synthetic
shipping lyophilized powder
purity ≥90% by RP-HPLC and SDS-PAGE analysis
molecular weight 17.107 Da by MS (calc 17.110 Da)
storage Powder at −20°C, solution at −80°C.
sample preparation For detailed sample preparation see product sheet.
regulatory statement For laboratory research use only, not for use in humans.
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