Biotin-K63 diUb-VME

Biotin-K63 diUb-VME


UbiQ-115 (Biotin-Ahx-K63 diUbiquitin VME) probe is a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs) based on K63 linked diUb. Here Lys63 has been replaced by a diaminobutyric acid residue equipped with a VME type warhead. The Dab(VME) type of structure is a DUB reactive mimic of the native isopeptidic linked Lys(Gly) residue. This DUB activity based probe can be used for activity profiling experiments and structural studies. Please note the native distance between the proximal and distal Ubiquitin is preserved as much as possible in UbiQ-115.

Product Attachments

View FileUbiQ-115 Productsheet B01062015-001
crystallizationpull downpurificationwestern blotphenotypic protein profiling

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name Biotin-K63 diUb-VME
product code UbiQ-115
Applications crystallization, pull down, purification, western blot, phenotypic protein profiling
target DUB
source human sequence, synthetic
shipping n/a
purity ≥90% by RP-HPLC and SDS-PAGE analysis
molecular weight 17.11 kDa
storage upon arrival, powder at −20°C and solution at −80°C.
sample preparation For detailed sample preparation see product sheet.
regulatory statement For laboratory research use only, not for use in humans.
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