UbiQ-156 is an activity based probe for SUMO proteases. It is based on the human SUMO2 sequence (C48S) in which the C-terminal is equipped with the electrophilic vinyl methyl ester (VME) group. The N-terminus is labeled with biotin and an aminohexanoic acid (Ahx) linker is used to create extra space between the biotin and SUMO2 protein for efficient access of biotin binding entities. It has been prepared by total chemical synthesis and is therefore well-defined in terms of biotinylation site.

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View File UbiQ-156 productsheet B01072016-001
crystallizationpull downpurificationwestern blotphenotypic protein profilingDUB activity profilingtarget inhibitor profiling

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name Biotin-Ahx-SUMO2-VME
product code UbiQ-156
Applications crystallization, pull down, purification, western blot, phenotypic protein profiling, DUB activity profiling, target inhibitor profiling
target SUMO 1,2,3, Ubl proteases
source human sequence, synthetic
shipping lyophilized powder
purity ≥95% by RP-HPLC
molecular weight 11.0 kDa
storage upon arrival, powder at −20°C; solution at −80°C.
sample preparation For detailed sample preparation see product sheet.
regulatory statement For laboratory research use only, not for use in humans.