DUB activity based probe explorer panel

DUB activity based probe explorer panel

details

UbiQ-L02 is a panel of the following 10 deubiquitylating enzyme (DUB) activity based probes (ABPs).

  VME PA
tag code name code name
- UbiQ-005 Ub-VME UbiQ-057 Ub-PA
HA UbiQ-035 HA-Ahx-Ahx-Ub-VME UbiQ-078 HA-Ahx-Ahx-Ub-PA
Biotin UbiQ-054 Biotin-Ahx-Ub-VME UbiQ-076 Biotin-Ahx-Ub-PA
TAMRA UbiQ-050 TAMRA-Ub-VME UbiQ-058 TAMRA-Ub-PA
Cy5 UbiQ-071 Cy5-Ub-VME UbiQ-072 Cy5-Ub-PA

 

All probes are prepared by total chemical synthesis. These DUB ABPs are potent, irreversible and specific inhibitors of DUBs which can be used for:

  1. inhibiting hydrolysis of poly-Ub chains on substrate proteins and thus enhancement of poly-Ub chain accumulation
  2. structural biology studies of DUB-Ub complexes
  3. DUB activity profiling experiments
  4. determine DUB inhibitor specificity

Product Attachments

View FileUbiQ-L02 Productsheet    Size: (890.79 KB)
crystallizationpull downpurificationwestern blotMSNMRphenotypic protein profiling

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€400.00

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€400.00

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mg
name DUB activity based probe explorer panel
product code UbiQ-L02
Applications crystallization, pull down, purification, western blot, MS, NMR, phenotypic protein profiling
target DUB
source human, synthetic
shipping lyophilized powder
purity n/a
molecular weight n/a
storage Powder at −20°C; solution at −80°C. Avoid multiple freeze/thaw cycles.
sample preparation For detailed sample preparation see product sheet.
regulatory statement For laboratory research use only, not for use in humans.
  • UbiQ-Probes crystallization overview download this pdf
  • UbiQ_DUB Probes factsheet download this pdf
  • UbiQ's drug discovery expertise overview

     

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